ABSTRACT\nBACKGROUND: To investigate prevalence, clinicopathological and inflammatory correlates of non-diabetic \nnephropathy and diabetic nephropathy in patients with type 2 diabetes \nMETHODS: A total of 138 patients with type 2 DM who underwent renal biopsy in a tertiary care nephrology clinic \nfrom 1990 to 2008 were analyzed retrospectively. Patients were divided into three groups based on renal biopsy findings \nincluding isolated nondiabetic nephropathy (NDN), isolated diabetic nephropathy (DN) and diabetic plus nondiabetic \nnephropathy (Mixed). Data on patient demographics, co-morbidities, duration of diabetes, indications and findings of \nrenal biopsy, serological markers, renal function, diabetic retinopathy (DRP), hemogram, blood biochemistry, urinalysis \nand inflammatory markers were recorded.\nRESULTS: Renal biopsy revealed NDN in 75.4% of patients (isolated in 66.7%) with FSGS (52.2%), membranous \nnephropathy (13.0%) and Ig A nephropathy (13.0%) as the most common diagnoses. DN was evident in 24.6% of \npatients. Mixed was evident in 10.1% of patients including DN superimposed with membranous nephropathy (28.6%), \nFSGS (21.4%), ATN (14.3%) or lupus nephritis (14.3%). In comparison with isolated DN and mixed nephropathy groups, \npatients in the isolated NDN group had significantly shorter diabetes duration, lower likelihood of DRP, lower serum \nlevels for creatinine and higher eGFR and LDL. Isolated NDN was also associated with significantly lower median NLR \nand and PLRvalues compared to isolated DN and mixed nephropathy groups, respectively.\nCONCLUSIONS: Our findings revealed the high prevalence of non-diabetic nephropathy, as presented mainly in the \nform of primary glomerular disease in isolated non-diabetic nephropathy. The shorter duration of diabetes, better renal \nfunction), lower likelihood of DRP seem to indicate the higher likelihood of isolated non-diabetic nephropathy.